Autoimmune Disease Cluster

A three-generation genogram demonstrating the familial clustering of multiple autoimmune conditions. The maternal grandmother had Hashimoto's thyroiditis, the mother has rheumatoid arthritis, a maternal aunt has systemic lupus erythematosus, the index patient has Crohn's disease, and a sister has celiac disease. HLA associations and the spectrum of autoimmune predisposition across the family are documented.